• Doç. Dr. OZAN ŞEN

Things to Know About Weight Loss Drugs

Weight loss drugs are one of the methods used from time to time in the fight against obesity. However, they were never very prominent. I think one of the most important reasons for this is its side effects, and the other is that no very effective appetite suppressant has been found so far. While some of the weight loss drugs have an appetite suppressant effect, some of them reduce the absorption of fats from the intestines. First of all, let's say that these drugs should be used under the supervision of a doctor. You may have heard from the media from time to time; News such as "he used weight loss medicine and lost his life". This point is particularly important. Let me state this up front

One of the most popular weight loss drugs these days is an injection with liraglutide active ingredient. This needle has an appetite suppressant feature. It looks like the insulin needle used by diabetics. This drug suppresses appetite by acting on the hormone GLP1. It is administered as daily injections. First, the application is started at a low dose and the dose is increased a little every week. If the desired weight loss is achieved at the end of 5 weeks, the treatment is continued. But if the person has not lost any weight after 5 weeks, the treatment is terminated. One of the major side effects of this drug is nausea. Nausea is so severe in some people that it is not possible to continue the treatment and increase the dose of the drug. One of the important points to know, Before starting this drug treatment, detailed blood tests and liver and other organ functions should be reviewed. In other words, these drugs are not drugs to be used according to your own mind. The last version of this appetite-suppressing needle treatment, which is stated to be more effective, has been put into use very recently, but it is not available in our country at the moment. It is stated that this drug has less nausea side effects and very effectively suppresses the appetite.

On the other hand, a drug called LORCASERIN, which was approved for use by the FDA in 2012, was withdrawn from the market in 2020 with concerns that it causes cancer. It was already known that this drug can cause certain heart problems. However, in a 5-year study on 12000 people, it was determined that cancer cases were more common in those who used this drug. Therefore, the use of the drug was discontinued.

There are also promising studies on weight loss drugs. One of these is a drug that is stated to both suppress appetite and accelerate fat burning. This drug is not yet ready for use, but human studies will begin soon.

These drugs still continue to be used in some patients who regain weight after bariatric surgery or in a group of people who do not meet the surgical criteria but cannot lose weight with diet. However, one should not expect a miracle from these drugs alone. Clients should be well informed that these drugs can only provide effective weight loss when combined with sports and a healthy diet.

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